Irresistible Cheesy Loaded Meatloaf Casserole Recipe

Name: Cheesy Loaded Meatloaf Casserole
Prep time: 15 min
Cook time: 50 min
Total time: 1 h 5 min
Cuisine: American
Ingredients: 1 lb ground beef (80/20); 1 cup plain or Italian breadcrumbs; 2 large eggs; 1 cup shredded cheddar cheese; 1 cup shredded mozzarella cheese; 1 medium onion, diced; 1 cup bell peppers, diced (any color); ½ cup ketchup; 1 tsp garlic powder; 1 tsp paprika; Salt and pepper to taste; Fresh parsley (optional for garnish)

Recipe By:

Stefanie Weber

Posted:

June 28, 2025

Updated:

June 28, 2025

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Cheesy Loaded Meatloaf Casserole is the ultimate comfort food that combines savory meat, gooey cheese, and hearty vegetables in a dish that warms the soul. Philly Cheesesteak Casserole Imagine diving into layers of tender meat infused with spices, all topped with melted cheese that stretches like a warm hug on a chilly night. Chicken Enchilada Soup For more inspiration, check out this Cheesy Mushroom Chicken Alfredo Lasagna recipe.

This dish brings back memories of family dinners where everyone gathered around the table, eagerly anticipating the delicious aroma wafting from the oven. Whether it’s a cozy weeknight meal or a festive gathering, Cheesy Loaded Meatloaf Casserole promises to delight your taste buds and create lasting memories.

[info_box title=”Why You’ll Love This Recipe”] The Cheesy Loaded Meatloaf Casserole is incredibly easy to prepare, making it perfect for busy weeknights. Each bite bursts with flavor thanks to its rich combination of cheeses and seasonings. Visually stunning, this casserole will impress guests at any dinner party. Versatile enough to customize with your favorite veggies or proteins, it adapts to any palate. [/info_box]

I once made this casserole for a family gathering, and the kids couldn’t get enough of it—my niece even declared it “better than pizza!”

Essential Ingredients

Here’s what you’ll need to make this delicious dish:

Ground Beef: Opt for 80/20 ground beef for optimal flavor and juiciness in your casserole. For more inspiration, check out this Ground Beef and Potatoes Casserole recipe.
Breadcrumbs: Use plain or Italian breadcrumbs to help bind the meatloaf together for a perfect texture.
Eggs: Two large eggs serve as a binder; they help keep everything moist and cohesive.
Shredded Cheese: A mix of cheddar and mozzarella creates that stretchy, gooey goodness we all crave.
Onion: Diced onions add sweetness; sauté them until translucent for maximum flavor.
Bell Peppers: Any color works! They add vibrant color and crunch to your casserole.
Ketchup: This classic topping adds sweetness and tang; feel free to get creative with your sauces!
Spices: Salt, pepper, garlic powder, and paprika will enhance the flavors beautifully. Garlic Parmesan Spaghetti Squash.
Fresh Parsley (optional): Chopped parsley adds a fresh pop of color and flavor as a garnish.

The full ingredients list, including measurements, is provided in the recipe card directly below.

Let’s Make it Together

Preheat Your Oven: Preheat your oven to 375°F (190°C). This ensures even baking for your casserole masterpiece.

Sauté the Vegetables: In a skillet over medium heat, add diced onions and bell peppers. Sauté until softened and aromatic—about five minutes should do it!

Mix the Meatloaf Ingredients: In a large bowl, combine ground beef, breadcrumbs, eggs, sautéed veggies, salt, pepper, garlic powder, and paprika. Mix until just combined—don’t overdo it!

Add Layers of Flavor: Spread half of the meat mixture into a greased baking dish. Top this layer with half of the shredded cheese; then add the remaining meat mixture on top.

Topping Time!: Spread ketchup evenly over the top layer of meatloaf. Sprinkle remaining cheese generously on top—this is where magic happens!

Bake Until Golden Brown: Place in preheated oven and bake for 45-50 minutes until golden brown and cooked through. You can check doneness by ensuring it reaches an internal temperature of 160°F (71°C).

Let it cool slightly before serving so you don’t burn your tongue on that glorious cheesy goodness! Enjoy every bite with friends or family—or treat yourself if no one’s watching!

Whether served with mashed potatoes or all on its own, Cheesy Loaded Meatloaf Casserole is bound to become a household favorite!

[info_box title=”You Must Know”] Cheesy Loaded Meatloaf Casserole is a comfort dish that combines classic flavors with a modern twist. The gooey cheese, savory meat, and hearty vegetables create a wonderful aroma that fills your kitchen. Perfect for family dinners or meal prep, it’s a guaranteed crowd-pleaser. [/info_box]

Perfecting the Cooking Process

Start by browning the meat in a skillet, then combine with veggies and seasonings. Bake until bubbly and golden to enhance flavors.

Add Your Touch

Feel free to swap Ground Turkey and Peppers or zucchini for extra nutrition and flavor.

Storing & Reheating

Store leftovers in an airtight container for up to three days. Reheat in the oven at 350°F until warmed through for best results.

[info_box title=”Chef’s Helpful Tips”] To achieve the perfect texture, don’t overmix the meat mixture; it can become tough. Consider using fresh herbs for added depth of flavor. If you want more heat, add crushed red pepper flakes to the mix. [/info_box]

Creating the Cheesy Loaded Meatloaf Casserole has been a game-changer for my family dinners. One time, my friend even asked for seconds before finishing their first plate!

FAQ

Can I use ground turkey instead of beef?

Yes, ground turkey works perfectly in this Cheesy Loaded Meatloaf Casserole.

How do I know when it’s fully cooked?

Ensure the internal temperature reaches 160°F for safe consumption.

Can I freeze leftovers?

Absolutely! Just store in an airtight container and freeze for up to three months.